Well: For DTaP Vaccine, Thigh May Be Better Injection Site Than Arm

Children are less likely to develop bad reactions to the DTaP vaccine, a routine immunization shot that protects against diphtheria, tetanus and pertussis, or whooping cough, if they get it in their thigh instead of in their arm, a new study shows.

The research looked at more than a million children who were given injections of the vaccine. In many cases it causes some degree of redness or swelling around the injection site, which typically goes away after a day. But in rare instances a child can develop a more pronounced reaction, like severe pain or a swollen limb, that may require medical attention.

In the new study, which was published in the journal Pediatrics, researchers found that children between the ages of 1 and 3 who were given the DTaP vaccine in their thigh instead of in their upper arm were around half as likely to have a local reaction that warranted a visit to a doctor, nurse or emergency room. Previous studies of children who received the vaccine between the ages of 4 and 6 found that they, too, had a lower likelihood of developing a local reaction requiring medical attention if they got the shot in their thigh instead of in their arm.

Why the vaccine would be less harsh on the thigh than the arm is not known for certain. But one possibility is simply that in children at that age, the thigh muscle is much larger than the deltoid, the muscle in the upper arm where shots are typically administered. If any inflammation ensues, it has more room to diffuse in the thigh, said Dr. Lisa A. Jackson, the lead author of the study and a senior investigator at the Group Health Research Institute in Seattle.

“In little kids the upper arm is very tiny,” she said. “You’re injecting the same volume of vaccine in the upper arm as in the thigh, which is a larger area. I think it’s just that it’s a larger muscle mass.”

The benefits, however, may not extend to other immunizations. The study, for example, also looked at shots for influenza and hepatitis A, and in those cases there was no meaningful difference between vaccinating in the arm or thigh for either toddlers or children ages 3 to 6.

In many cases, doctors choose where to administer a shot according to their own preference. But in the case of DTaP, at least, it makes more sense in general to give the shot in the thigh, Dr. Jackson said.

“Unless there’s a compelling reason not to, I would say veer toward giving the DTaP vaccine in the leg,” she said. “There’s less chance of a concerning reaction if you give it in the thigh versus the arm. So that should be the normal practice.”

Dr. Jackson stressed, however, that the absolute risk of a child having a reaction severe enough to warrant medical attention is still quite small, regardless of whether the shot is given in the arm or leg. The study found that it occurred in less than 1 percent of vaccinated children over all.

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Roche Hires Dr. John Reed to Lead Research Operations

The Swiss pharmaceutical giant Roche is turning to a prolific American academic scientist to revitalize its lagging research operations.

Dr. John C. Reed, the chief executive of the Sanford-Burnham Medical Research Institute in San Diego, will become head of Roche’s pharmaceutical research and early development group in April, the company announced Tuesday.

Dr. Reed, 54, has spent 21 years at Sanford-Burnham, formerly known as the Burnham Institute, the last 11 as chief executive.

During his tenure as chief executive, the institute grew rapidly, opened a new research site in Florida, and broadened its role from basic research to also doing drug discovery, in some cases in collaborations with pharmaceutical companies. It also received its largest donation ever, $50 million, from the credit card industry executive T. Denny Sanford, which led the institute to change its name.

Dr. Reed, 54, who holds both a medical degree and a Ph.D., is the author of more than 800 scientific papers, many dealing with why cancer cells do not commit suicide as errant cells are supposed to do. A triathlete, Dr. Reed used to get to his office around 3:30 a.m. each day, though now, with better computers, he works at home in the early hours.

“With his broad scientific and medical background, he is ideally positioned to drive Roche’s strategy of translating a better understanding of disease mechanisms into promising therapeutics,” Severin Schwan, the chief of Roche, said in a statement.

It is not unprecedented for drug companies to tap academic scientists to run research. Sanofi’s research and development is now run by Elias Zerhouni, the former director of the National Institutes of Health and professor at Johns Hopkins. Mark Fishman, a cardiologist at Harvard, was recruited to run research at Novartis, and Peter S. Kim, who heads research at Merck, was previously a biology professor at the Massachusetts Institute of Technology.

Dr. Reed, who has been on biotechnology company boards but never had a full-time corporate job, said in an interview that he was joining Roche to “have an opportunity to contribute on a larger stage, so to speak.”

At Roche he will oversee not only research but also early- and middle-stage clinical trials, something Sanford-Burnham does not do. He will supervise about 2,000 people with an annual budget in the billions, while Sanford-Burnham has about 1,200 people and a budget of around $175 million.

Dr. Reed, who will move to Basel, where Roche is based, said it was too early to discuss his agenda at Roche, other than to make its research more collaborative.

The operation Dr. Reed will run, called Pharma Research and Early Development, or pRED, does not include Genentech, the California biotechnology company that Roche fully acquired in 2009. In an effort to preserve the culture at Genentech, Roche left it autonomous, forming a group it calls gRED.

Recently, gRED has been eclipsing pRED. Roche’s three best-selling drugs, the cancer medicines Rituxan, Herceptin and Avastin, were developed at Genentech. So have some of its most attractive experimental drugs, including T-DM1, a breast cancer drug that could win regulatory approval early this year.

The organization Dr. Reed will run, by contrast, has had its share of problems in recent years. Several hundred researchers were cut in a corporate reorganization. And last year Roche discontinued development of a heart drug after it failed to work in a late-stage clinical trial.

The troubles contributed to Roche’s decision in June to shut its campus in Nutley, N.J., the birthplace of valium. At that time, Jean-Jacques Garaud, head of the Roche unit that Dr. Reed will run, left the company and was replaced on an interim basis by Mike Burgess. Roche said Tuesday that Mr. Burgess would now also leave the company.

Sanford-Burnham said that Dr. Kristiina Vuori, its president and head of its cancer center, would take over as chief executive on an interim basis. Dr. Vuori, who is originally from Finland, has worked closely with Dr. Reed.

M. Wainwright Fishburn Jr., the chairman of Sanford-Burnham, said it was “bittersweet” to see Dr. Reed leave. While the institute will lose a very successful leader, he said, the move could advance the institute’s efforts to get drug discovery work from pharmaceutical companies.

“We have one of our own in one of the most influential positions around,” he said.

This article has been revised to reflect the following correction:

Correction: January 15, 2013

A headline with an earlier version of this article misspelled the name of the drug maker. It is Roche, not Roches.

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IHT Rendezvous: 2012: The Year of Extreme Weather

The weather reports are in. 2012 was the hottest and the most extreme year on record in many places.

While parts of China are enduring the harshest winter in 30 years, the Antarctic is warming at an alarming rate. In Australia, out of control bushfires are partially the result of record-breaking weather (new colors were added to weather forecast maps, to account for the new kind of heat). In the United States, where Hurricane Sandy devastated parts of New Jersey and New York and where extreme drought still lingers in the Midwest, the average temperature in 2012 was more than a whole degree Fahrenheit (or 5/9 of a degree Celsius) higher than average – shattering the record.

On Friday a long-term weather forecast for the United States was released, when the National Climate Assessment and Development Advisory Committee published a draft of the third Climate Assessment Report. Like last year’s weather, the assessment does not pull its punches.

“Climate change threatens human health and well-being in many ways, including impacts from increased extreme weather events, wildfire, decreased air quality, diseases transmitted by insects, food, and water, and threats to mental health,” write the authors as part of their key findings.

Experts from 13 federal agencies, including NASA, the State Department and the Department of Defense put together the report under the auspices of the United States Global Change Research Program.

While some predictions have been adjusted upward from previous reports, the difference in tone in this newest assessment is striking. The second assessment, published in 2009, predicted of thresholds that will be crossed, while the 2013 draft presents a reality in which some of the changes are already irreversible.

“As a result of past emissions of heat-trapping gases, some amount of additional climate change and related impacts is now unavoidable,” wrote the authors in the executive summary.

Adaptation to climate change is discussed in the new draft, which is open for public comment before it is officially released early in 2014. The authors write:

Planning and managing based on the climate of the last century means that tolerances of some infrastructure and species will be exceeded. For example, building codes and landscaping ordinances will likely need to be updated not only for energy efficiency, but also to conserve water supplies, protect against insects that spread disease, reduce susceptibility to heat stress, and improve protection against extreme events.

The authors predict that within the next several decades, temperatures will go up between 2 and 4 degrees Fahrenheit, roughly 1 and 2 degrees Celsius. The experts discuss a possible 10 degree Fahrenheit (or more than 5 degrees Celsius) warming by the end of the century, in the case that not enough is done to curb emissions. (The World Bank recently released a report of the dangers of a world warmed by 4 degrees Celsius).

Sea levels could rise up to four feet, or 1.2 meters, within the century, according to the experts.

Though official assessments, predictions and studies like these serve to reinforce what many already fear, they do not necessarily lead to policy change. Andrew Restuccia predicted in a Politico article that the new report would ultimately do little to change the embittered climate-change politics in that country. He wrote:

But don’t hold your breath for serious action on climate change in Congress. Republicans and some moderate Democrats remain opposed to measures to address climate change. The Obama administration, meanwhile, is moving forward with its own efforts on climate change, including beefed-up fuel economy standards and greenhouse gas regulations for new power plants.

Sometimes official assessment reports provide substance for those who question man-made climate change.

My colleague Andrew C. Revkin recently reported on how a revision by Britain’s Weather and Climate Agency on short-term global temperature forecast became fodder for climate change deniers. The fact that the government agency had revised its numbers downward allowed climate change skeptics to argue that the world was not significantly warming after all.

In December, Alec Rawls, a climate-change skeptic, made a name for himself by leaking an unpublished Assessment Report from the Intergovernmental Panel on Climate Change, one of the major global players in climate change assessment. Mr. Rawls tried to argue that the panel’s language on solar radiation was an admission that much of the warming trends were caused by the sun, not human activity.

As Andrew reported at time, his claims were mostly debunked.

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Come for a Tour of China’s Unlicensed ‘World of Warcraft’ Theme Park

World of Warcraft Theme Park

Image credit Francesca Timbers

Click here to view this gallery.

[More from Mashable: 20 Tweets That Prove Skittles’ Social-Media Team Inhaled the Rainbow]

Changzhou, China is home to a bizzarre world of rides, food and fun: A World of Warcraft-style theme park that’s completely unlicensed by Blizzard, maker of the Warcraft series.

The park opened in the summer of last year. It reportedly cost $ 48 million to build and is “pretty huge,” according to Reddit user Francesca Timbers who originally posted these pictures republished here with permission.

[More from Mashable: 10 Amusing Cubicle Makeovers [VIDEOS]]

“I thought it was great,” posted Timbers. “A lot of the rides used 4-D and special effects, which I hand’t experienced much of before. There was a good roller coaster with loops, where you are lying horizontally, face forward, like you are flying. That was my favourite ride. The water log ride (‘splash of monster blood’) was pretty good too.”

Another weird tidbit: Some rides have a “happiness index,” showing, we believe, the intensity of the ride.

While most of the park is Warcraft-flavored, one section is dedicated to another Blizzard favorite: Starcraft.

For the rest of Timbers’ pictures and more details about her trip to the utterly weird theme park, visit her Reddit thread. Would you book a trip to China to get out to this theme park?

Images courtesy Francesca Timbers

This story originally published on Mashable here.

Gaming News Headlines – Yahoo! News

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Title games feature Ravens-Pats, 49ers-Falcons

One game is a rematch. The other might feel like one — at least to one of the teams.

For the second straight year in the AFC, the New England Patriots will host the Baltimore Ravens with a trip to the Super Bowl on the line.

In the NFC, it will be San Francisco traveling to Atlanta, with the Falcons defense trying to stop a versatile, running quarterback for the second straight week.

"Russell Wilson and Colin Kaepernick are mobile quarterbacks who throw the ball at extremely accurate levels," Falcons safety Thomas DeCoud said. "We can use this game as a cheat sheet to prepare for next week."

On Sunday, the Falcons barely got past Wilson and the Seattle Seahawks, who overcame a 20-point deficit to take a one-point lead, but gave it up after Matt Ryan drove Atlanta into field goal range and Matt Bryant made a 49-yard kick with 8 seconds left.

Atlanta is the only team not making a repeat appearance in the NFL's final four. Last year, it was the Giants playing, and beating, the 49ers for the NFC title.

On Saturday, Kaepernick passed for 263 yards and rushed for 181 — a playoff record for a quarterback — to defeat Green Bay 45-31.

"We're one step closer to where we want to be," said Kaepernick. San Francisco hasn't been to the Super Bowl since 1995, when Steve Young led the 49ers to their fifth Lombardi Trophy.

Though the Niners must travel cross country for the game, they opened as 3-point favorites in a meeting of teams that played twice a year until 2003, when Atlanta was moved from the NFC West to the NFC South. Their only previous playoff meeting was a 20-18 win for the Falcons in the 1998 divisional playoffs. Atlanta won at Minnesota the next week to make its only Super Bowl.

San Francisco's 20-17 overtime loss last year to the Giants was part of a tense day of football that began with New England's 23-20 victory over the Ravens in the AFC title game.

In that game, Billy Cundiff missed a 32-yard field goal that would have tied the game with 11 seconds left.

This season, Justin Tucker beat out Cundiff for the kicker's job. Tucker hit a 47-yarder against Denver on Saturday to lift the Ravens to a 38-35 win in double overtime, extending Ray Lewis' career for at least one more week and putting the 17-year veteran one win away from his second Super Bowl.

"We fought hard to get back to this point and we're definitely proud of being here," Ravens quarterback Joe Flacco said. "We feel like it's going to take a lot for somebody to come and kick us off that field come the AFC championship game."

Lewis and the Ravens will have to stop the NFL's most potent offense. The Patriots put up 457 yards in a 41-28 victory over Houston, which left them one win away from their sixth Super Bowl in the 2000s.

"I think the two best teams are in the final," Patriots quarterback Tom Brady said. "Baltimore certainly deserve to be here and so do we."

The Patriots were made early 9½-point favorites against the Ravens.

These teams met in the regular season and that game was also decided by a kick — Tucker's 27-yard field goal that sneaked through the right upright for a 31-30 victory. Or did it?

While the Ravens were celebrating, Pats coach Bill Belichick ran to midfield and grabbed a replacement official's arm as he tried to exit the field. The NFL fined Belichick $50,000 for the gesture.

New England is the even-money favorite in Vegas to win the Super Bowl. San Francisco is next at 2-1, followed by Atlanta (5-1) and Baltimore (8-1).

Among the possible Super Bowl story lines:

—The Harbaugh Bowl. Jim Harbaugh coaches the 49ers and John Harbaugh coaches the Ravens.

—A rematch of San Francisco's 41-34 win at New England on Dec. 16 — one of the most entertaining games of the regular season.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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Recipes for Health: Skillet Beet and Farro Salad

“Comforting” isn’t a word I usually associate with salads, but this week I put together five grain salads that fit that bill. Over the years I have developed a number of delicious whole grain salads that combine various grains with vegetables, herbs and often nuts, tossed in a tangy dressing. I have also married many a grain and vegetable in a pilaf. I decided to bring both concepts together in hearty salads that I’m calling “skillet salads;” each one is heated through in a skillet just before serving.

You can get ahead on all of these by cooking the grains or noodles ahead. Whole grains freeze well and keep in the refrigerator for three days. Then it’s just a question of preparing vegetables, herbs and dressing. Even if you don’t cook the grains ahead you can prepare the other ingredients while they’re simmering.

I make a meal of these at lunch, and serve smaller portions as sides or starters for dinner. If you want to serve the warm, tangy grains on a bed of salad greens I recommend spinach or sturdy greens like frisée or dandelion greens that will stand up to the heat of the salad and won’t wilt beyond recognition when topped with something warm.

Skillet Beet and Farro Salad

This hearty winter salad can be a meal or a side dish, and warming it in the skillet makes it particularly comforting. Cook your farro until you see that the grains have begun to splay so they won’t be too chewy and can absorb the dressing properly.

For the Salad:

2 medium or 3 small beets, roasted

1 cup farro, soaked for 1 hour in 1 quart water

Salt to taste

1 ounce lightly toasted pistachios (scant 1/4 cup)

1/4 cup chopped fresh herbs, such as parsley, tarragon, marjoram, chives, mint

Freshly ground pepper

For the Dressing:

2 tablespoons sherry vinegar

1 teaspoon balsamic vinegar

Salt to taste

1 small garlic clove, minced or pureéd

1 teaspoon Dijon mustard

1/3 cup extra virgin olive oil

2 tablespoons walnut oil

Crumbled feta for garnish (optional)

1. Roast the beets and meanwhile cook the farro. Place in a medium saucepan with the soaking water and bring to a boil. Add salt to taste, reduce the heat, cover and simmer 45 minutes to an hour, until the grains have begun to splay. Turn off the heat and allow to sit for 15 minutes or longer in the water. Drain through a strainer set over a bowl.

2. While the farro is cooking, make the vinaigrette. Whisk together the vinegars, salt, garlic, and mustard. Whisk in the oils. Pour into a wide frying pan or saucepan and add to the farro, along with a couple of tablespoons of the farro cooking water. Peel and dice the beets and add, along with the herbs and pistachios. Stir over medium heat until heated through and serve, with a little feta sprinkled over the top if you wish.

Yield: Serves 6

Advance preparation: The cooked farro and the roasted beats will keep for 3 or 4 days in the refrigerator.

Nutritional information per serving (6 servings): 304 calories; 19 grams fat; 2 grams saturated fat; 5 grams polyunsaturated fat; 11 grams monounsaturated fat; 0 milligrams cholesterol; 27 grams carbohydrates; 3 grams dietary fiber; 61 milligrams sodium (does not include salt to taste); 6 grams protein

Note: If you want to reduce the fat and calories in this dish, substitute buttermilk for some of the oil. Be careful not to allow the dressing to come to a boil when you heat it in the pan or the buttermilk will curdle.

Martha Rose Shulman is the author of “The Very Best of Recipes for Health.”

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DealBook: With U.P.S. Deal, European Antitrust Regulators Block Another Big Merger

European antitrust regulators proved again on Monday that they were more than willing to flex their considerable muscle.

U.P.S.‘s $6.9 billion bid for TNT Express is the latest merger blocked by the European Union, and certainly the most prominent since the proposed tie-up of NYSE Euronext and Deutsche Börse last year. In the case of U.P.S., European regulators argued that proposed asset sales, including airline operations, would not be enough to appease their concerns over the state of competitiveness in package delivery.

“We are extremely disappointed with the European Commission’s position,” the chief executive of U.P.S., D. Scott Davis, said in a statement. “We proposed significant and tangible remedies designed to address the European Commission’s concerns with the transaction.”

Other antitrust regulators have blocked mergers on antitrust grounds. For example, the Justice Department opposed AT&T‘s proposed $39 billion bid for T-Mobile USA.

But the European Commission, led by Joaquín Almunia, has displayed an aggressive approach that has rankled some deal makers.

Mr. Almunia has acknowledged those concerns, even as he has sought to rebut them. In a speech delivered in November, the commissioner argued that he was not trying to prevent European companies from growing. But he said he was trying to preserve a competitive market place.

“It is simply not true that the commission is putting the brakes on the legitimate efforts of Europe’s firms to scale up,” he said. “What we must avoid are attempts to shield Europe’s companies from competition, in particular during this harsh period for the economy. In this game, only a few of them will benefit, and the majority will lose.”

Among Mr. Almunia’s arguments was that the European Commission was less concerned about high levels of market share than what mergers might do to prices.

In the case of the NYSE Euronext merger, regulators demanded that the two exchange operators sell off significant parts of their businesses. Chief among the European Union’s concerns were the strong position that the two companies would have in the market for derivatives traded on exchanges, leading to a call for the sale of either NYSE Euronext’s Liffe platform or Deutsche Börse’s Eurex unit.

Both companies protested, arguing that the European Union’s view of the market was too limited and did not take into account the broader market for derivatives traded off exchanges. The market operators eventually decided to call off their deal, believing that there was little hope for reversing regulators’ opinion.

Other deals have passed review, but some have required significant changes. In approving Universal Music Group’s takeover of EMI Music last year, for example, European regulators required the sale of a third of EMI’s assets. The decision has led to the auction of music labels like Parlaphone, the home to groups like Coldplay and David Guetta.

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India Ink: Woman Raped by Seven Men in Punjab, India, Police Say

NEW DELHI — Police said Sunday that a  29-year-old woman had been raped by a bus driver, a bus conductor and five other men in the north Indian state of Punjab, in an incident that recalls the recent attack in Delhi that has caused widespread outrage.

The woman boarded a bus on Friday bound for Gurdaspur, to visit her in-laws, the police chief of Gurdaspur, Raj Jit Singh, said in a telephone interview. When she got off the bus, the driver offered her a ride on his motorcycle, perhaps to her in-laws village, the police said. Instead, he took her to a nearby village where he and six other men, including the bus conductor, raped her repeatedly through the night.

The next morning, the driver dropped her at her in-laws home, where the woman told her family members of the incident, and then reported it to the police, Mr. Singh said.

Six men, including the bus driver and conductor, have been arrested, he said. All of the men are their twenties.

Gurmesh Singh, the deputy superintendent of police for the  region, said it was unclear how or why the bus driver persuaded the woman to go with him on his motorcycle. She was in a state of distress during the bus ride, Mr. Singh said, and originally refused to get off of the bus when it reached its final destination.

The Press Trust of India reported that the bus driver did not stop at her stop when requested.

The gang-rape of a woman on a moving bus in New Delhi on Dec. 16, and her subsequent death from injuries sustained during the rape, has sparked widespread protests and calls for increased policing and tougher laws against sexual assault in India.

The case against five of the men arrested in that rape is being heard this month in a special fast-track court created just for incidents of sexual assault.

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Women pry open door to video game industry’s boys’ club

SAN FRANCISCO (Reuters) – When video game developer Brenda Brathwaite Romero started her career in the 1980s, she could count the number of female developers in the industry on one hand.

Today, many “Women in Games” roundtables she attends are filled to capacity with new faces. The 46-year-old, sometimes referred to as the longest-serving woman in the video game arena, jokes that these days one can even encounter long lines for the ladies’ room at the Game Developers Conference, one of the industry’s largest gatherings.

“Over the years, greatly helped by the social and mobile boom, there have been many, many women coming into game development,” Brathwaite Romero said.

With women comprising just over 1 in 10 in the video game workforce, the industry has a reputation for being among the most testosterone-fueled of the traditionally male-dominated technology sector. But thanks to the mobile revolution, industry executives say that’s changing.

With smartphones going mainstream and delivering gaming to a new, broader population, publishers and developers are keen to tap an audience beyond young males. And, not surprisingly, as women have explored a growing range of mobile games on Facebook or other platforms, they have discovered the allure of working in the industry.

The number of women hired by game companies has tripled since 2009, according to recruiting firm VonChurch, based on over 350 placements it has made in digital gaming firms like CrowdStar and GREE.

In 1989, when veteran games designer Sheri Graner Ray started out, women made up less than 3 percent of the workforce. That’s now up to 11 percent.

“In 20 years, it’s not a lot of growth,” said Graner Ray, who has worked at leading companies like Electronic Arts and Sony Online Entertainment. But she agrees that number will rise as more women assert themselves in the industry, educational programs take hold, and mobile games continue to flourish.

Some of the first engineers at mobile games maker Pocket Gems were women, and though that wasn’t intentional when the company was founded in 2009, it proved instrumental to success, said Chief Executive Ben Liu.

Pocket Gems, best known as a maker of family-friendly mobile games like its popular “Tap” series, recently launched “Campus Life”, where players can build and run a college sorority, to target a female audience.

“I’ve worked at other, different game companies and I’ve been on floors where it’s only guys,” Liu said. “Our aspiration is to create games that are mass market and accessible to all people, and having that representative base of employees helps us keep true to that.”

DEBAUCHERY ‘WAY, WAY DOWN’

Gaming still conjures up images of young men glued to flickering screens for hours on end, fueled by energy drinks and waging online battles unto death in such “shooters” as “Call of Duty” or tactical war games like “Starcraft.”

But the advent of affordable smartphones and tablets and the burgeoning world of social media has drawn in a whole new world of gamers. Individuals who had never been tempted to plunk down hundreds of dollars to buy a gaming console found themselves enticed by a whole new genre of games.

These days, gaming might just as easily mean launching attacks on pigs in “Angry Birds” or slicing produce with swiping motions in “Fruit Ninja” — games that have mass appeal.

“Mobile is still the Wild West and it’s founded on this idea of inclusion, because everyone has these mobile devices and everyone wants to play,” said game content designer Elizabeth Sampat, who works at social game company Storm8.

That’s partly why more than half of America’s social and mobile gamers are women, according to research firm EEDAR, while they comprise just 30 percent of those who play hard-core violent games like Microsoft’s “Halo 4″ on game consoles.

Erin McCarty, 24, grew up playing such fare. She went to engineering school at Carnegie Mellon University, with a goal toward working in the video game industry.

Today she’s the only female engineer in a seven-member team crafting multiplayer-shooter game “Realm of the Mad God” at social and mobile game company Kabam that targets male gamers.

But far from feeling different, McCarty considers herself just another coder at Kabam, where women make up just a fifth of the payroll.

“I’m around guys a lot and they are always people that I’m happy to work with,” McCarty said.

Brathwaite Romero recalls how her male coworkers on the team that created the mature-rated “Playboy: The Mansion” game with nude characters that was published in 2005, were wholly professional.

“I’ve fortunately not experienced the level of misogyny that I’ve heard other people experience,” Brathwaite Romero said.

“Some of the debauchery that was evident in the early days of the industry, like meetings at strip clubs, having strippers at your party, that sort of stuff has gone down way, way down from where it used to be.”

DANCING GIRLS AND SEXISM

That’s not to say the industry doesn’t have a ways to go.

First, there’s a 27 percent gap in average incomes, with women making $ 68,062 versus men at $ 86,418, according to Game Developer Magazine’s 2011 annual salary survey.

Women in the game industry are underrepresented in software engineering and top-level management, reflecting a similar trend in the broader technology sector, industry executives say.

VonChurch found engineering positions were skewed more toward men in their placements since 2009. Female engineers made up 21 percent from the pool of women it placed, while over half of the men it placed were hired in engineering positions.

Then there are the occasional throwbacks to the male-dominated 1980s and 1990s. Gameloft created a stir a few weeks ago after a holiday party at its Montreal studio ran amok.

The studio, which makes games for devices like Apple Inc’s iPhone, hired a burlesque dance troupe that featured scantily clad women in body paint. By the end of the evening, several dancers began to discard their bathing suits, according to a person with knowledge of the event, who asked not be named.

The dancers were expelled from the event “as soon as their misconduct was brought to light,” Gameloft said in a statement.

Over a month ago, a tweet from a male gaming professional — “Why are there so few women in gaming?” — ignited a top-trending Twitter conversation under the #1reasonwhy hashtag, that quickly morphed into a now infamous discussion of discrimination and sexism in the workplace.

“I was told I’d be remembered not on my own merits, but by who I was or was assumed to be sleeping with,” Seattle-based pen and paper game designer Lillian Cohen-Moore, who goes by @lilyorit, tweeted.

Gaming conventions can bring out the worst in attendees, said several women gaming professionals. While not a pure work environment, they are a forum for professionals from across the industry to convene to talk shop and do business.

Cohen-Moore, 28, said she was appalled to see men at the annual Penny Arcade Expo in Seattle groping women working as costumed characters when she worked there last year.

“I’ve been leery about transitioning into video games because the culture over there is a lot more blatant and active in how many sex trolls they have,” she said.

Brathwaite Romero, who is married to industry legend and “Doom” creator John Romero, also recounts a jarring instance at last summer’s Electronic Entertainment Expo, the industry’s biggest gathering.

“I was discussing a potential contract with somebody and the guy right next to me is talking about — to quote him — ‘the tits and ass’ on this particular model. And he’s going on and on and on about this,” she said. “This is wrong.”

Sampat said in some workplaces, though not at her current employer Storm8, women are often expected to tolerate off-color jokes – of which they’re often the target.

Before stepping into an interview at an online game company a couple of years ago, Sampat said a female human resources employee told her: “It’s my job to make sure that all potential candidates can, you know, take a joke.”

“I couldn’t help but wonder if she asked the white male programmer who came in before me whether he could take a joke too,” Sampat said.

Women outside the United States find similar challenges. Alisa Chumachenko, CEO and founder of Game Insight, a fast-growing mobile and social company in Russia, thinks having more women in senior and more diverse roles will help. Her company of 450 employees has three other women in high-level positions, but she wishes she knew more women in gaming.

“We need to really look at the women who have become movers and shakers in this industry,” the veteran games designer Graner Ray said, “and claim them and hold them up and say: ‘Here’s where we are, here’s what we can do. Pay attention to us.’”

(Editing by Edwin Chan and Leslie Adler)

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Ravens shock Broncos; 49ers rout Packers

The 49ers and Ravens are getting another shot at making the Super Bowl.

Losers in tight conference championship games a year ago, they are returning to the final step before the big game in the Big Easy after wins Saturday.

Baltimore took the long, frigid route, rallying at Denver for a 38-35 victory in an AFC divisional playoff. The Ravens will go to either New England, where they lost 23-20 in the conference championship match last January, or Houston. The Patriots and Texans face off Sunday in Foxborough, Mass.

San Francisco took the NFC game at night 45-31 over Green Bay behind the running and passing of quarterback Colin Kaepernick. That gave both coaching Harbaughs victories Saturday: Jim with the 49ers, John with the Ravens.

San Francisco fell in overtime to the New York Giants for the NFC title last year. The Niners will either visit Atlanta or host Seattle in next weekend's championship matchup.

The wild-card Seahawks are at the Falcons in Sunday's early game.

Second-year QB Kaepernick made Jim Harbaugh's decision to stick with him over incumbent Alex Smith during the season look brilliant. He set a playoff mark for the position by rushing for 183 yards, including a 56-yard TD, and threw for 263 yards. Kaepernick hit Michael Crabtree for two scores and Frank Gore rushed for 119 yards.

The AFC West champion Niners (12-4-1) gained 579 yards.

"It feels like we're in the same place," Crabtree said. "Winning that game last year, we're in the same place. It's just what we do the next game. It's all about the next game."

The NFC North-winning Packers (12-6) beat Minnesota in the wild-card round last weekend, but their defense was overmatched at San Francisco.

Aaron Rodgers finished 26 for 39 for 257 with two TDs and an interception.

Ravens 38, Broncos 35, 2 OT

Rookie Justin Tucker's 47-yard field goal 1:42 into the second overtime of the longest playoff game in 26 years advanced the Ravens and kept star linebacker Ray Lewis' career going at least another week.

Earlier this season, the AFC North champ Ravens (12-6) beat the Patriots 31-30 in Baltimore. They lost 43-13 at Houston.

Joe Flacco's 70-yard heave to Jacoby Jones with 31 seconds remaining forced the overtime. Flacco is the only quarterback to win playoff games in each of his first five seasons, and he heads to his third AFC championship match. He also lost to Pittsburgh in the 2008 title game.

"We fought hard to get back to this point and we're definitely proud of being here." Flacco said. "We feel like it's going to take a lot for somebody to come and kick us off that field come the AFC championship game."

Lewis announced before they beat Indianapolis in the wild-card round that this was the last of his 17 pro seasons. It's still going.

"When you look back at it and let the emotions calm down, it will probably be one of the greatest victories in Ravens history," Lewis said. "It's partly because of the way everything was stacked against us coming in."

Peyton Manning lost in his first postseason appearance with the AFC West-winning Broncos (13-4), who had won their last 11 games to earn home-field advantage in the playoffs. They wasted it by giving up long plays, negating a record-setting performance by kick returner Trindon Holliday.

Holliday ran back the second-half kickoff 104 yards for a TD. He went 90 yards with a first-quarter punt return to become the first player to score on one of each in a playoff game.

"He's one of the greatest quarterbacks of all time and for us to come in here and confuse him the way we did, and make the plays we did?" Lewis said. "We gave up two big special teams touchdowns, but the bottom line is, but we kept fighting."

Seahawks (12-5) at Falcons (13-3)

Oddly, there might be more doubts floating around the home team with the spiffy record than the visitors.

While Seattle has won six in a row, erased its reputation as a road flop with three straight away victories — including last week at Washington — and has the league's stingiest defense.

It's NFC South champ Atlanta, 0-3 in the postseason under coach Mike Smith and with Matt Ryan at quarterback, that probably faces more pressure.

"We've been disappointed a few times," said center Todd McClure, a Falcon for 13 years. "I think we've got guys in this locker room who are hungry and ready to get over that hump."

One of them is Tony Gonzalez, the career leader in nearly all receiving categories among tight ends. In 16 pro seasons, Gonzalez never has won a playoff game. And he's said this very likely is his final year in the NFL.

"I'm not going to lie to you," he said. "I really, really, really want to win this game."

To get it, Gonzalez, Ryan and star receivers Julio Jones and Roddy White must contend with the league's most physical defense, a unit that completely shut down the Redskins for three quarters in the 24-14 wild-card win.

"I expect our guys to try to play like they always play," Seattle coach Pete Carroll said. "They don't need to change anything because we're not doing anything different, we're going to try and hang with them, and we'll find out what happens."

Texans (13-4) at Patriots (12-4)

Houston's reward for its wild-card win over Cincinnati is a return to trip to Foxborough, where the Texans' late-season spiral began. Houston was in position for home-field advantage in the AFC before being routed 42-14 by the Patriots, then losing twice more in the final three games.

This is only the fourth postseason game in the Texans' 11-season NFL history. The Patriots began winning Super Bowls with Tom Brady before the Texans were born.

AFC South champion Houston must bring the fierce pass rush it often has shown with end J.J. Watt, who led the NFL with 20 1-2 sacks.

"Biggest goal of them all, Super Bowl, and this is a big step for us," Watt said, "and we're really excited about the challenge."

That challenge comes against the NFL's most prolific offense. The Texans and Patriots allowed the same number of points, 331, but AFC East winner New England led the NFL in scoring with 557 points, 34.8 per game.

Brady would surpass Joe Montana for most postseason victories by a quarterback by beating Houston. Brady is 16-6, although he began 10-0.

He isn't looking for a repeat of the Dec. 10 romp.

"Giving us an opportunity to have this game at home, I think that's the important thing about last game," Brady said. "Other than that, this is going to be a whole different game full of our own execution, our ability to try to beat a very good football team that's played well all year."

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